22. 出典・付録

この章では、本文の根拠を追えるように出典をまとめる。制度や海外要件は変わるため、実際に使う時は最新版を見る。

22-1. 出典

ここから先は、本文で参照した資料。

一次情報、公的資料、添付文書、CDC Pink Bookなどを中心に置いた。

リンクは2026-06-06時点で確認したもの。制度や海外要件は変わりうるので、実際に使う時は最新版を確認する。

22-2. 出典 1

S1. 厚生労働省「5種混合ワクチン」
https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/kenkou/kekkaku-kansenshou/yobou-sesshu/vaccine/dpt-ipv-hib/index.html

S2. PMDA「ゴービック水性懸濁注シリンジ 添付文書」2026年5月改訂
https://www.pmda.go.jp/PmdaSearch/iyakuDetail/630144_636140FG1020_1_09

S3. PMDA「クイントバック水性懸濁注射用 添付文書」
https://www.info.pmda.go.jp/go/pdf/261976_636140FG2027_1_03

S33. PMDA「ゴービック水性懸濁注シリンジ 申請資料概要 2.5 臨床に関する概括評価」
https://www.pmda.go.jp/drugs/2023/P20230411001/630144000_30500AMX00111_G100_1.pdf

S34. PMDA「クイントバック水性懸濁注射用 申請資料概要」
https://www.pmda.go.jp/drugs/2023/P20230828001/261976000_30500AMX00275_B100_1.pdf

22-3. 出典 2

S4. JIHS「IDWR 2025年第22号 注目すべき感染症 百日咳」
https://id-info.jihs.go.jp/surveillance/idwr/jp/attention/2025/22/index.html

S5. JIHS「百日咳 2025年11月現在」
https://id-info.jihs.go.jp/surveillance/iasr/pathogens/vol47/551/551t.html

S35. JIHS「2025年における届出ガイドラインに則った国内百日咳の疫学のまとめ」
https://id-info.jihs.go.jp/surveillance/iasr/pathogens/vol47/551/551r03.html

S36. 総務省統計局「人口推計」
https://www.stat.go.jp/data/jinsui/index.html

S6. JIHS「破傷風とは」および厚労省5種混合ページ内説明

S7. 厚生労働省 副反応検討部会資料2-17
https://www.mhlw.go.jp/content/11120000/001475795.pdf

22-4. 出典 3

S8. 厚生労働省「予防接種法第5条第1項の規定による予防接種の実施について」一部改正
https://www.mhlw.go.jp/web/t_doc?dataId=00tc8498&dataType=1&pageNo=1

S9. 厚生労働省「ワクチンの接種間隔」
https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/kenkou/kekkaku-kansenshou03/rota_index_00003.html

S10. 厚生労働省「ポリオとポリオワクチンの基礎知識」
https://www.mhlw.go.jp/bunya/kenkou/polio/qa.html

22-5. 出典 4

S11. FDA「Common Ingredients in FDA-Approved Vaccines」
https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/common-ingredients-fda-approved-vaccines

S12. CDC「Adjuvants and Vaccines」
https://www.cdc.gov/vaccine-safety/about/adjuvants.html

S13. McNeil et al. “Risk of anaphylaxis after vaccination in children and adults.” PubMed
https://pubmed.ncbi.nlm.nih.gov/26452420/

S37. McNeil et al. “Vaccine-associated hypersensitivity.” J Allergy Clin Immunol, 2018
https://pmc.ncbi.nlm.nih.gov/articles/PMC6602527/

S38. Taylor et al. “Vaccines are not associated with autism: an evidence-based meta-analysis.” Vaccine, 2014
https://pubmed.ncbi.nlm.nih.gov/24814559/

S39. Hviid et al. “Measles, Mumps, Rubella Vaccination and Autism.” Ann Intern Med, 2019
https://pubmed.ncbi.nlm.nih.gov/30831578/

S40. DeStefano et al. “Increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines is not associated with risk of autism.” J Pediatr, 2013
https://pubmed.ncbi.nlm.nih.gov/23545349/

S44. Gidengil et al. “Safety of Vaccines Used for Routine Immunization in the United States: An Update.” AHRQ Comparative Effectiveness Review, 2021
https://www.ncbi.nlm.nih.gov/books/NBK572043/

S45. Hansen et al. “Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers.” Vaccine, 2016
https://pubmed.ncbi.nlm.nih.gov/27510380/

22-6. 出典 5

S14. CDC「State Vaccination Requirements」
https://www.cdc.gov/vaccines/php/requirements-laws/state-vaccination-requirements.html

S15. Australian Government「Immunisations for access to family assistance benefits and early childhood services」
https://www.health.gov.au/topics/immunisation/when-to-get-vaccinated/immunisations-for-access-to-family-assistance-benefits-and-early-childhood-services

S16. Singapore MOH「Childhood Developmental Screening and Childhood Vaccinations」
https://www.moh.gov.sg/managing-expenses/schemes-and-subsidies/childhood-developmental-screening-and-childhood-vaccinations/

22-7. 出典 6

S17. Singapore MOH「Measles and Diphtheria Vaccination Coverages and Requirements for Foreign Students Aged 12 Years and Below」
https://www.moh.gov.sg/newsroom/measles-and-diphtheria-vaccination-coverages-and-requirements-for-foreign-students-aged-12-years-and-below/

S18. European Vaccination Information Portal「Mandatory or recommended vaccination」
https://vaccination-info.europa.eu/en/vaccination/when-vaccinate/mandatory-or-recommended-vaccination

S19. ECDC「Vaccination schedules for individual European countries」
https://www.ecdc.europa.eu/en/immunisation-vaccines/EU-vaccination-schedules

22-8. 出典 7

S20. WHO「Recommendations to assure the quality, safety and efficacy of diphtheria vaccines」
https://www.who.int/docs/default-source/biologicals/vaccine-standardization/diphtheria/diphtheria-recommendations-trs-980-annex-4.pdf

S21. CDC Pink Book「Chapter 7: Diphtheria」
https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-7-diphtheria.html

S22. CDC Pink Book「Chapter 21: Tetanus」
https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-21-tetanus.html

S41. CDC「Contraindications and Precautions」
https://www.cdc.gov/vaccines/hcp/imz-best-practices/contraindications-precautions.html

S42. CDC「Polio Disease and Poliovirus Containment」
https://www.cdc.gov/poliovirus-containment/diseaseandvirus/index.html

S43. CDC「COVID-19 Vaccine Safety」
https://www.cdc.gov/vaccine-safety/vaccines/covid-19.html

22-9. 出典 8

S23. CDC Pink Book「Chapter 8: Haemophilus influenzae」
https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-8-haemophilus-influenzae.html

S46. CDC「Haemophilus influenzae Disease Surveillance and Trends」
https://www.cdc.gov/hi-disease/php/surveillance/index.html

S47. CDC MMWR「Tetanus Surveillance — United States, 2009–2023」
https://www.cdc.gov/mmwr/volumes/75/ss/ss7501a1.htm

S48. WHO「Vaccine-preventable diseases surveillance standards: Haemophilus influenzae」
https://www.who.int/publications/m/item/vaccine-preventable-diseases-surveillance-standards-haemophilus-influenzae

S49. CDC「Clinical Overview of Poliomyelitis」
https://www.cdc.gov/polio/hcp/clinical-overview/index.html

S24. CDC「Adjuvants and Vaccines」
https://www.cdc.gov/vaccine-safety/about/adjuvants.html

S25. HogenEsch et al.「The mechanisms of action of vaccines containing aluminum adjuvants」
https://pmc.ncbi.nlm.nih.gov/articles/PMC4406982/

S26. Del Giudice et al.「Polysaccharide conjugate vaccine protein carriers as a neglected valency」
https://www.sciencedirect.com/science/article/pii/S0264410X17305790

22-10. 出典 9

S27. 厚生労働省「予防接種健康被害救済制度について」
https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/vaccine_kenkouhigaikyuusai.html

S28. 厚生労働省「予防接種法に基づく医師等の報告のお願い」
https://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou20/hukuhannou_houkoku/

S29. Australian Government「Immunisation requirements for family assistance and early childhood services」
https://www.health.gov.au/topics/immunisation/when-to-get-vaccinated/immunisations-for-access-to-family-assistance-benefits-and-early-childhood-services

22-11. 出典 10

S30. CDC Pink Book「Chapter 16: Pertussis」
https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-16-pertussis.html

S31. CDC Pink Book「Chapter 18: Poliomyelitis」
https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-18-poliomyelitis.html

S32. CDC「Diphtheria, Tetanus, and Pertussis Vaccine Recommendations」
https://www.cdc.gov/vaccines/vpd/dtap-tdap-td/hcp/

22-12. 出典 11

S50. PAHO/WHO「Epidemiological Update Pertussis (Whooping Cough) in the Americas Region」2026年3月25日
https://www.paho.org/en/documents/epidemiological-update-pertussis-whooping-cough-americas-region-25-march-2026

S51. CDC MMWR「Pertussis Deaths — United States, 2000」
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5128a2.htm

S52. WHO EMRO「Haemophilus influenzae type B: Disease burden」
https://www.emro.who.int/health-topics/haemophilus-influenzae-type-b/disease-burden.html

S53. CDC Emerging Infectious Diseases「Haemophilus influenzae Type b Meningitis in Infants, New York, New York, USA, 2022–2023」2025年
https://wwwnc.cdc.gov/eid/article/31/3/24-0946_article/

S54. WHO「Diphtheria」Fact sheet, 2024年7月12日
https://www.who.int/news-room/fact-sheets/detail/diphtheria

22-13. 出典 12

S55. WHO「Diphtheria - African Region (AFRO)」Disease Outbreak News, 2025年
https://www.who.int/southeastasia/outbreaks-and-emergencies/disease-outbreak-news/item/DON588

S56. Berger et al.「Autochthonous outbreak of respiratory diphtheria caused by Corynebacterium diphtheriae, Germany, September 2024」Euro Surveill, 2025
https://edoc.rki.de/handle/176904/12990?locale-attribute=en

S57. CDC MMWR「Progress Toward Achieving and Sustaining Maternal and Neonatal Tetanus Elimination — Worldwide, 2000–2022」2024
https://www.cdc.gov/mmwr/volumes/73/wr/mm7328a1.htm

S58. CDC MMWR「Notes from the Field: Tetanus in an Unvaccinated Child — Oregon, 2017」
https://www.cdc.gov/mmwr/volumes/68/wr/mm6809a3.htm

S59. WHO「Statement of the Forty-fourth Meeting of the Polio IHR Emergency Committee」2026年3月4日
https://www.who.int/philippines/news/detail-global/04-03-2026-statement-of-the-forty-fourth-meeting-of-the-polio-ihr-emergency-committee

S60. CDC MMWR「Public Health Response to a Case of Paralytic Poliomyelitis in an Unvaccinated Person and Detection of Poliovirus in Wastewater — New York, June–August 2022」
https://www.cdc.gov/mmwr/volumes/71/wr/mm7133e2.htm

22-14. 出典 13

S61. CDC Travelers' Health「Routine Vaccines」
https://wwwnc.cdc.gov/travel/page/routine-vaccines

S62. CDC Yellow Book「Travel Vaccine Recommendations for Infants and Children」
https://www.cdc.gov/yellow-book/hcp/family-travel/travel-vaccine-recommendations-for-infants-and-children.html

S63. CDC「Polio Vaccination for International Travelers」
https://www.cdc.gov/polio/vaccines/international-travelers.html

S64. Australian Government「National Immunisation Program Schedule」
https://www.health.gov.au/sites/default/files/2026-05/national-immunisation-program-schedule.pdf

S65. HealthHub Singapore「National Childhood Immunisation Schedule (NCIS)」
https://www.healthhub.sg/sites/assets/Assets/eServices/HPB-DB-Immunisation-Schedule.pdf

S66. CDC「Vaccination: Technical Instructions for Civil Surgeons」
https://www.cdc.gov/immigrant-refugee-health/hcp/civil-surgeons/vaccination.html

22-15. 出典 14

S67. CDC MMWR「Pertussis Epidemic — California, 2014」
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6348a2.htm

S68. CDC MMWR「Invasive Haemophilus influenzae Type B Disease in Five Young Children — Minnesota, 2008」
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5803a4.htm

S69. CDC MMWR「Diphtheria Epidemic — New Independent States of the Former Soviet Union, 1990-1994」
https://www.cdc.gov/Mmwr/preview/mmwrhtml/00036527.htm

S70. CDC MMWR「Tetanus Surveillance — United States, 2009–2023」2026年
https://www.cdc.gov/mmwr/volumes/75/ss/ss7501a1.htm

22-16. 出典 15

S71. WHO「WHO Epidemiological Brief: Tajikistan polio outbreak and regional response: No. 3」2010年7月19日
https://iris.who.int/handle/10665/368438

S72. CDC MMWR「Outbreaks Following Wild Poliovirus Importations — Europe, Africa, and Asia, January 2009–September 2010」
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5943a1.htm

22-17. 出典を読む順番

迷ったら、この順番で読むと追いやすい。

1. 厚労省5種混合ページ（制度と概要）
2. PMDA添付文書（成分、副反応、注意）
3. PMDA申請資料（臨床試験と免疫原性）
4. CDC Pink Book（病気とワクチンの基本）
5. AHRQレビュー（米国定期接種の安全性）
6. 個別論文（アナフィラキシー、自閉症、DTaP-IPV/Hib）

先にSNSを見るより、元資料を一度見た方が話が安定する。